Sedating tricyclic

05 Feb

Since their discovery in the 1950s, tricyclic antidepressants have been used to treat mental depression.Like other antidepressant drugs, they reduce symptoms such as extreme sadness, hopelessness, and lack of energy.

Named for their three-ring chemical structure, tricyclic antidepressants work by correcting chemical imbalances in the brain.Examples of nonsedating antidepressants include the monoamine oxidase inhibitor moclobemide, the selective serotonin reuptake inhibitors fluoxetine, paroxetine, and nefazodone, and the serotonin and norepinephrine uptake inhibitor (SNRI) venlafaxine.The effect of antidepressants on driving behavior was assessed with the standard deviation of lateral position (SDLP) test.It enhances central noradrenergic and serotonergic activity by blocking alpha10Mirtazapine is well absorbed without regard to food intake.It demonstrates linear kinetics over its usual dosage range and reaches peak plasma level approximately two hours after an oral dose.11 The elimination half-life is 20 to 40 hours, so a steady state is reached in approximately five days.